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Wham is created for paired-conclude Illumina libraries with standard insert dimensions (~300bp-500bp). Wham integrates mate-pair mapping, break up study mapping, tender-clipping, different alignment and consensus sequence based mostly evidence to forecast SV breakpoints with single-nucleotide accuracy. Wham generates a blended pileup (catalog of re
The tender-clipped sequences that overhang the breakpoint are collapsed right into a consensus sequence using a multiple sequence alignment (MSA) delivered from the seqAn library [27]. Wham applies 3 filters to the consensus sequences. Breakpoints usually are not reported in conditions in which consensus sequences are shorter than ten bp or compris
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